What is Topotecan?

CAS: 123948-87-8

Molecular Formula: C23H23N3O5

Molecular Weight: 421.45

Topotecan is a semisynthetic acquired of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian timberline Camptotheca acuminata. Topotecan inhibits topoisomerase I action by stabilizing the topoisomerase I-DNA covalent complexes during S appearance of corpuscle cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA break and bearing potentially baleful double-strand DNA break if encountered by the DNA archetype machinery.

Topotecan is used to amusement baby corpuscle lung blight (a blazon of blight that begins in the lungs) that was auspiciously advised with a altered chemotherapy medication but has alternate no eventually than 45 canicule afterwards the endure dosage of the aboriginal chemotherapy medication was taken. Topotecan is in a chic of medications alleged topoisomerase I inhibitors. It works by killing blight cells.