Daunorubicin hydrochloride is a DNA intercalating anthracylcine accustomed artefact
abandoned from Streptomyces peucetius. Upon intercalation, Daunorubicin forms
abiding complexes with the DNA backbone, inhibiting accustomed action of the
bifold braid and the proteins that collaborate with it. Daunorubicin is about
identical in anatomy to Doxorubicin (sc-200923), with Doxorubicin absolute a
chaplet hydroxyl accumulation on the exocyclic ketone. The action of
Daunorubicin has been activated to ability in suppressing the admeasurement of
assertive astute leukemias. Daunorubicin hydrochloride is an inhibitor of Topo
I and Topo II and an activator of LASS.
Daunorubicin
Hydrochloride has antimitotic and cytotoxic action through a amount of proposed
mechanisms of action. Daunorubicin Hydrochloride forms complexes with DNA by
intercalation amid abject pairs. It inhibits topoisomerase II action by
stabilizing the DNA-topoisomerase II complex, preventing the religation
allocation of the ligation-religation acknowledgment that topoisomerase II
catalyzes. Single fiber and bifold fiber DNA break result.
Daunorubicin
Hydrochloride may aswell arrest polymerase activity, affect adjustment of gene
expression, and aftermath chargeless abolitionist accident to DNA.
Daunorubicin
Hydrochloride possesses an antitumor aftereffect adjoin a advanced spectrum of
beastly tumors, either grafted or spontaneous.
