Daunorubicin Hydrochloride Mechanism of Action

Daunorubicin hydrochloride is a DNA intercalating anthracylcine accustomed artefact abandoned from Streptomyces peucetius. Upon intercalation, Daunorubicin forms abiding complexes with the DNA backbone, inhibiting accustomed action of the bifold braid and the proteins that collaborate with it. Daunorubicin is about identical in anatomy to Doxorubicin (sc-200923), with Doxorubicin absolute a chaplet hydroxyl accumulation on the exocyclic ketone. The action of Daunorubicin has been activated to ability in suppressing the admeasurement of assertive astute leukemias. Daunorubicin hydrochloride is an inhibitor of Topo I and Topo II and an activator of LASS.

Daunorubicin Hydrochloride has antimitotic and cytotoxic action through a amount of proposed mechanisms of action. Daunorubicin Hydrochloride forms complexes with DNA by intercalation amid abject pairs. It inhibits topoisomerase II action by stabilizing the DNA-topoisomerase II complex, preventing the religation allocation of the ligation-religation acknowledgment that topoisomerase II catalyzes. Single fiber and bifold fiber DNA break result.

Daunorubicin Hydrochloride may aswell arrest polymerase activity, affect adjustment of gene expression, and aftermath chargeless abolitionist accident to DNA.

Daunorubicin Hydrochloride possesses an antitumor aftereffect adjoin a advanced spectrum of beastly tumors, either grafted or spontaneous.