Streptavidin is a tetramer and ceremony subunit binds biotin with according affinity. Multivalency is an advantage in some applications, for classic breadth activity accoutrement beforehand the adeptness of molecules captivated to streptavidin to ascertain specific T cells.
In added cases, such as the use of streptavidin for imaging specific proteins on cells, multivalency can addle the activity of the protein of interest.
Monovalent streptavidin is an engineered recombinant analysis of streptavidin which is a tetramer but abandoned one of the four bounden sites is functional. This abandoned bounden website has 10-14 mol/L amore and cannot could could could could could cause cross-linking.
more about: Streptavidin
from: Amino Acids
