Amifostine Indications

Amifostine is used therapeutically to abate the accident of neutropenia-related agitation and infection induced by DNA-binding chemotherapeutic agents including alkylating agents (e.g. cyclophosphamide) and platinum-containing agents (e.g. cisplatin). It is aswell used to abatement the accumulative nephrotoxicity associated with platinum-containing agents. Amifostine is aswell adumbrated to abate the accident of xerostomia in patients ability radiotherapy for arch and close cancer.

Amifostine was originally adumbrated to abate the accumulative renal toxicity from cisplatin in non-small corpuscle lung cancer. However, while nephroprotection was observed, the anticipation that amifostine could assure tumors could not be excluded. Additional abstracts accept crystalline that amifostine-mediated bump protection, in any analytic scenario, is unlikely.