CAS:
320-67-2
Molecular
Formula: C8H12N4O5
Molecular
Weight: 244.2
Azacitidine
is an alternation of cytidine, one of the nucleosides which accomplish up nucleic
acids. When azacitidine is congenital into DNA it inhibits DNA
methyltransferase, abbreviation hypermethylation, and has a absolute cytotoxic
aftereffect on abnormally proliferating cells.
Azacitidine
is used to amusement myelodysplastic affection (a accumulation of altitude in
which the cartilage bottom produces claret beef that are agee and does not
aftermath abundant advantageous claret cells). Azacitidine is in a chic of
medications called demethylation agents. It works by allowance the cartilage
bottom to aftermath accustomed claret beef and by killing aberrant beef in the
cartilage marrow.It is aswell an antimetabolite of cytidine, congenital
primarily into RNA. Azacytidine has been used as an antineoplastic agent.
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