Fluphenazine Mechanism of Injury

Fluphenazine is a trifluoro-methyl phenothiazine acquired advised for the administration of schizophrenia and added certifiable disorders. Fluphenazine has not been credible able in the administration of behaviorial complications in patients with brainy retardation.

Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the absolution of hypothalamic and hypophyseal hormones and is believed to abase the baffling activating arrangement appropriately affecting basal metabolism, physique temperature, wakefulness, vasomotor tone, and emesis.

The apparatus by which fluphenazine and added phenothiazines could cause serum aminotransferase elevations is not known. Many aspects of the analytic presentation of phenothiazine hepatotoxicity (short cessation period, fever, eosinophilia) advance a hypersensitivity reaction, and rechallenge about causes a accelerated ceremony of injury. Fluphenazine is abundantly metabolized by the alarmist via sulfoxidation and oxidation, and some instances of serum aminotransferase elevations as able-bodied as added clinically credible alarmist abrasion may be acquired by assembly of a baneful average of its metabolism.