What is Motesanib Diphosphate?

Motesanib Diphosphate has ample action adjoin the animal VEGFR family, and displays >1000 selectivity adjoin EGFR, Src, and p38 kinase. Motesanib Diphosphate decidedly inhibits VEGF-induced cellular admeasurement of HUVECs with an IC50 of 10 nM, while announcement little effect at bFGF-induced admeasurement with an IC50 of >3,000 nM.

Motesanib Diphosphate aswell potently inhibits PDGF-induced admeasurement and SCF-induced c-kit phosphorylation with IC50 of 207 nM and 37 nM, respectively, but not able adjoin the EGF-induced EGFR phosphorylation and corpuscle action of A431 cells.Althouth announcement little antiproliferative action on corpuscle advance of HUVECs alone, Motesanib Diphosphate analysis decidedly sensitizes the beef to fractionated radiation.