Chlorpropamide Description

Chlorpropamide is an articulate antihyperglycemic abettor used for the analysis of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea chic of insulin secretagogues, which act by aesthetic β beef of the pancreas to absolution insulin. Sulfonylureas access both basal insulin beard and meal-stimulated insulin release. Medications in this chic alter in their dose, amount of absorption, continuance of action, avenue of abolishment and bounden website on their ambition pancreatic β corpuscle receptor. Sulfonylureas aswell access borderline glucose utilization, abatement hepatic gluconeogenesis and may access the amount and acuteness of insulin receptors. Sulfonylureas are associated with weight gain, admitting beneath so than insulin. Due to their apparatus of action, sulfonylureas may could cause hypoglycemia and crave constant aliment assimilation to abatement this risk. The accident of hypoglycemia is added in elderly, debilitated and angular individuals.

Chlorpropamide is not recommended for the analysis of NIDDM as it increases claret burden and the accident of retinopathy (UKPDS-33). Up to 80% of the individual articulate dosage of chlorpropramide is metabolized, acceptable in the liver; 80-90% of the dosage is excreted in urine as banausic biologic and metabolites. Renal and hepatic dysfunction may access the accident of hypoglycemia.