Gossypol side effects

The all-embracing trials of gossypol in Chinese men appear an abnormally top amount of hypokalemia a part of subjects, capricious from 1-10%. Hypokalemia is characterized by low levels of potassium in the blood. Potassium is one of the elements acclimated by the anatomy and fretfulness to address signals. Symptoms of low claret potassium cover fatigue, beef weakness and at its a lot of extreme, paralysis. Hypokalemia is usually the aftereffect of branch malfunction, and can be acquired by boundless burning of diuretics. Advisers do not accept absolutely how gossypol affects the kidneys.

Several studies of gossypol as a contraceptive in macho monkeys approved to antidote potassium accident by giving the monkeys a circadian potassium supplement. The supplement did not stop the monkeys from accident potassium and the advisers assured that hypokalemia was an assured ancillary aftereffect (Lohiya 1990, Kumar 1997).

However, the dosage the monkeys accustomed was college than the agnate dosage accustomed to men, and there is affirmation that the accident of hypokalemia depends on dosage. Two added studies of gossypol as a low-dose contraceptive in men address no incidences of hypokalemia (Gu 2000, Coutinho 2000). Dr. Elsimar Coutinho (2002) of Brazil contends that antecedent letters of hypokalemia were the aftereffect of “the Chinese diet, which is poor in potassium, and not to the aftereffect of gossypol on the kidneys.”

Regardless of gossypol’s accessible causal accord with hypokalemia, advisers at the World Health Organization (WHO) accept added apropos about ancillary effects. Gossypol is a accepted toxin, and a baneful dosage is beneath than 10 times the contraceptive dose. Some altercate that this abandoned should disqualify it from added study.