What is Ascomycin?

Ascomycin, aswell called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with able immunosuppressant properties. It has been researched for the analysis of autoimmune diseases and derma diseases, and to anticipate bounce afterwards an agency transplant.

Ascomycin acts by bounden to immunophilins, abnormally macrophilin-12. It appears that Ascomycin inhibits the assembly of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular basic of the atopic response. Ascomycin produces a added careful immunomodulatory effect in that it inhibits the extract appearance of allergic acquaintance dermatitis but does not blemish the primary allowed acknowledgment if administered systemically.

Ascomycin is produced by the beverage of Streptomyces hygroscopicus.