Tetomilast Description

Tetomilast, aswell accepted as OPC6535, is a atypical thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove advantageous in both the analysis of anarchic bowel ache (IBD) and abiding adverse pulmonary ache (COPD). Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative accent in rabbits. Tetomilast suppressed assembly of proinflammatory cytokines from animal monocytes and ameliorated abiding colitis in IL-10-deficient mice.

Tetomilast has been used in trials belief the analysis of Crohn Disease, Colitis, Ulcerative, and Abiding Adverse Pulmonary Disease.